Cetaphil Deep Hydration Face Serum — Fragrance-Free 1 oz, Sensitive Skin, 48‑Hour Hydration

Cetaphil Deep Hydration Face Serum is a lightweight, fragrance-free serum that delivers up to 48 hours of replenishing hydration while being gentle on sensitive skin.

This serum from Cetaphil is formulated to quickly absorb and restore moisture balance without heavy oils or irritation. It combines a HydroSensitiv Complex with hyaluronic acid, sunflower seed oil, vitamin B5 and vitamin E to support skin that feels tight, dry, or temporarily dehydrated. The texture layers smoothly under moisturizers and makeup, making it a practical step in both morning and evening routines for those seeking long-lasting hydration from a dermatologist-recommended brand.

How does this serum hydrate skin for up to 48 hours?

The formula uses a targeted hydration complex to help skin retain moisture and reduce the appearance of dryness over time. Hyaluronic acid attracts and holds water in the skin, while supportive emollients help seal in that hydration for longer-lasting comfort.

• HydroSensitiv Complex helps improve dynamic hydration
• Hyaluronic acid draws and retains moisture
• Sunflower seed oil helps reinforce the skin’s natural barrier
• Vitamin B5 and vitamin E add soothing and antioxidant support

Will this serum irritate sensitive or reactive skin?

Cetaphil designed this serum to be gentle: it’s fragrance-free and clinically tested on sensitive skin to minimize the chance of irritation. The lightweight, non-comedogenic formula absorbs quickly so it won’t leave a greasy residue that can feel heavy on delicate skin.

• Fragrance-free formulation reduces irritation risk
• Non-comedogenic texture won’t clog pores
• Clinically tested on sensitive skin for tolerability
• Can be used alone or layered under creams and SPF

How do I use this serum within my skincare routine?

Apply to clean, dry skin after cleansing and any water-based treatments (like toners) and before thicker creams or oils. A few drops are sufficient—gently press the serum into the face and neck until absorbed, then follow with moisturizer and sunscreen in the morning.

• Use morning and/or night on cleansed skin
• Apply 2–3 drops to face and neck, press in gently
• Layer under your favorite day cream, moisturizer, or sunscreen
• Compatible with makeup application once absorbed

What key ingredients should I expect and what do they do?

The ingredient blend balances humectants, emollients and supportive vitamins to hydrate and comfort skin without heaviness. These ingredients work together to rehydrate the surface while supporting the skin’s appearance and resilience.

• Hyaluronic acid — attracts and holds moisture in the skin
• Sunflower seed oil — lightweight emollient that helps protect the barrier
• Vitamin B5 — supports skin’s hydration and softness
• Vitamin E — antioxidant support to help maintain skin appearance

Who is this for? Cetaphil Deep Hydration Face Serum is suited for people with sensitive, dry, or dehydrated skin seeking a mild, easily layered product to boost moisture retention. It’s practical for anyone who prefers fragrance-free, dermatologist-tested formulas that integrate cleanly into existing skincare routines—especially those who want long-lasting hydration without a heavy finish.

Ingredients

Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside